We only include what the evidence supports.
And we only make claims the research can back. Every ingredient, every dose, every form is chosen for a specific biological reason grounded in human clinical evidence.
The biology of why sleep matters more than anything else.
Your brain runs a waste-clearance system called the glymphatic system, a network of channels that opens almost exclusively during deep sleep to flush out the metabolic waste that accumulates during waking hours. This includes amyloid beta, the protein linked to Alzheimer's disease, and tau proteins associated with neurodegeneration and cognitive decline.
The 2013 Science paper by Lulu Xie and colleagues at the University of Rochester established the mechanism directly: the glymphatic system is nearly ten times more active during sleep than wakefulness. The brain's interstitial space expands by 60% during sleep, allowing cerebrospinal fluid to flush through at a rate impossible while awake. Matthew Walker's subsequent research documented the population-level consequences: chronic disruption of deep sleep is one of the strongest modifiable risk factors for Alzheimer's disease identified to date.
The glymphatic system does not run when you are awake. It does not run during light sleep. It runs in deep sleep, the stage most directly disrupted by elevated cortisol and magnesium deficiency. This is the problem Glym Drop is designed to address. Not just how you feel in the morning. What happens inside your brain every single night.
Oxford Academic research puts the population-level consequence plainly: chronic poor sleep has a greater impact on life expectancy than poor diet or lack of exercise. That is not a wellness talking point. It is what the longitudinal data shows.
The two biological causes of disrupted sleep.
Elevated cortisol
Cortisol follows a diurnal rhythm: it should peak in the morning, fall through the afternoon, and reach its lowest point around sleep onset. Chronic stress, late-night screens, irregular schedules, and high training load all push cortisol up at night, keeping the nervous system in an alert state when it should be winding down. The result is not just difficulty falling asleep but disrupted sleep architecture throughout the night, particularly in the second half when cortisol naturally begins to rise again toward morning. Ashwagandha KSM-66 at 300mg is one of the most clinically validated interventions for reducing cortisol. In a randomised controlled trial published in the Indian Journal of Psychological Medicine (2012), participants taking 300mg twice daily showed a 27.9% reduction in serum cortisol.
Magnesium deficiency
Magnesium is involved in over 300 enzymatic processes, including the regulation of the GABA receptor, which is the primary inhibitory neurotransmitter responsible for calming the nervous system. Magnesium also regulates the HPA axis, which controls cortisol secretion. Subclinical magnesium deficiency is estimated to affect 30 to 50 percent of the Australian adult population. The mechanism is well established: low magnesium leads to elevated cortisol and reduced GABA activity, both of which directly degrade sleep quality. Magnesium glycinate is the form with the highest bioavailability and the lowest rate of digestive side effects. The dose in Glym Drop is scaled to body weight, because magnesium requirements scale with mass. A 60kg person and a 100kg person do not have the same need.
How we choose what goes in.
Only what has human trial evidence.
Every ingredient in Glym Drop is backed by randomised controlled trials in humans. Animal studies and in-vitro research are not sufficient. We include ingredients because the evidence in people says they work at the doses we use.
Doses that match the research.
The dose in each clinical trial matters. An ingredient at a sub-therapeutic dose is not evidence of efficacy. Every dose in Glym Drop matches or exceeds the doses used in the trials that demonstrated effectiveness.
Forms that actually absorb.
Magnesium oxide is cheap and poorly absorbed. Magnesium glycinate is expensive and highly bioavailable. We chose the form that works. KSM-66 is the standardised, clinically studied extract of ashwagandha. Generic root powder contains variable concentrations of the compounds that do the actual work.
What we do not claim.
Glym Drop is a listed complementary medicine under Australian TGA guidelines (AUST L [number]). It has been assessed for safety and quality. It is not a drug and does not treat, cure, or diagnose any medical condition.
We do not claim it works for everyone. We claim it addresses the most common biological causes of disrupted sleep with well-evidenced ingredients at therapeutic doses. For most people, that is sufficient. For some people, the problem is something else, and the Glym app is designed to help identify what that might be.
If you have a diagnosed sleep disorder, consult your doctor. Always read the label and follow the directions for use. If symptoms persist, consult your healthcare professional.
See the formula.
Every ingredient, every dose, every form explained.